COVID-19 SERO-PREVALENCE AND BEHAVIOUR SURVEY (i)
The primary objective of the survey is:
??? To determine the extent of COVID-19 virus infection in the general population and age-specific infection prevalence, as determined by seropositivity;
??? To determine the fraction of asymptomatic or subclinical COVID-19 infections;
??? To determine the incidence rate of COVID-19 infections as determined by change from negative to positive serostatus in an embedded cohort of respondents in metropolitan municipalities (viz., Cape Town, Durban, Johannesburg and Nelson Mandela Bay).
The secondary objectives of the study are:
a) To determine risk factors for COVID-19 virus infection
b) To estimate the prevalence of Covid-19 antibodies in age and sex sub-groups
c) To assess antibody levels quantitatively and neutralising antibody concentrations for future comparisons with correlates of protection for herd immunity estimations
d) To assess cytotoxic T-cell responses in a sub-group of respondents who have and do not have antibody responses, in order to identify what proportion of individuals may have been infected with SARS-CoV-2 but do not have detectable antibodies.