South African research ethics committee review of standards of prevention in HIV vaccine trial protocols

SOURCE: Journal of Empirical Research on Human Research Ethics
OUTPUT TYPE: Journal Article
PUBLICATION YEAR: 2018
TITLE AUTHOR(S): Z.Essack, D.R.Wassenaar
KEYWORDS: ETHICS, HIV/AIDS, HIV/AIDS PREVENTION, RESEARCH
Print: HSRC Library: shelf number 10561
HANDLE: 20.500.11910/12760

If you would like to obtain a copy of this Research Output, please contact Hanlie Baudin at researchoutputs@hsrc.ac.za.

Abstract

HIV prevention trials provide a prevention package to participants to help prevent HIV acquisition. As new prevention methods are proven effective, this raises ethical and scientific design complexities regarding the prevention package or standard of prevention. Given its high HIV incidence and prevalence, South Africa has become a hub for HIV prevention research. For this reason, it is critical to study the implementation of relevant ethical-legal frameworks for such research in South Africa. This qualitative study used in-depth interviews to explore the practices and perspectives of eight members of South African research ethics committees (RECs) who have reviewed protocols for HIV vaccine trials. Their practices and perspectives are compared with ethics guideline requirements for standards of prevention.