Self-report and dry blood spot measurement of antiretroviral medications as markers of adherence in pregnant women in rural South Africa

SOURCE: AIDS and Behavior
OUTPUT TYPE: Journal Article
PUBLICATION YEAR: 2017
TITLE AUTHOR(S): M.L.Alcaide, S.Ramlagan, V.J.Rodriquez, R.Cook, K.Peltzer, S.M.Weiss, S.Sifunda, D.L.Jones
KEYWORDS: ANTIRETROVIRAL THERAPY, HIV/AIDS, PREGNANCY, RURAL COMMUNITIES
DEPARTMENT: Social Aspects of Public Health (SAPH)
Print: HSRC Library: shelf number 9744

If you would like to obtain a copy of this Research Output, please contact Hanlie Baudin at researchoutputs@hsrc.ac.za.

Abstract

Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N = 392 HIV-infected pregnantwomen in SouthAfrica (SA).Women completed two self-reported adherence measures [visual analog scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measuresmarginally agreed withDBS(VAS:Kappa = 0.101, Area under the ROC curve (AUROC) = 0.543; ACTG: Kappa = 0.081,AUROC = 0.538). Self-reported adherence was overestimated and agreement with DBS was poor. Validation of self-reportedARVadherence among pregnant HIV women in SA is needed.