As the world changes rapidly, we are faced with new ways of knowing and being. At the 2018 Science Forum South Africa, five academics posed difficult questions and provided fresh insights on knowledge and power and the possibilities presented by “pluriversality”, the idea that various forms of knowledge and ways of knowing are equally valuable. Many critics have raised questions about knowledge, power, production and consumption, often focusing on specifics rather than the fundamentals. Chaired by Prof Narnia Bohler-Muller, the focus of this discussion was on “intellectual liberation” as a reflexive, deliberate, and necessary intellectual project that would require a fundamental questioning of knowledge production and consumption practices.